Persons suffering from G-6PD deficiency are resistant to malaria. Expl – InterviewSolution

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1.	Persons suffering from G-6PD deficiency are resistant to malaria. Explain.
Answer» G-6PD is an enzyme glucose 6 phosphate dehydrogenase which decomposes H₂C₂ formed during metabolism. The deficiency of this enzyme is an inborn error of metabolism controlled by specific gene. When persons suffering from malaria are given Primaquine it causes haemolysis because H₂O₂ produced during metabolism is not decomposed due to the deficiency of G-6PD enzymes. This H₂O₂ haemolysis the blood. The haemoglobin of haemolysed blood collects on cell membrane and RBC’s are deformed. In such distorted RBC’s, malarial parasite fails to survive and multiply. It means persons suffering from G-6PD deficiency are resistant to malaria. Such persons are, therefore, favoured by natural selection in area infested with malarial parasite. For this reason, G-6PD deficiency is found in 50% Negroes living in areas with malarial infection in African countries.

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