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Question : At a particular locus, frequency of allete A is 0.6 and that of allele a is 0.4. what would be the frequency of heterozygotes in a random mating population at equilibrium?

Answer»

0.36
0.16
0.24
0.48

Solution :In a STABLE population, for a GENE with two alleles, 'A' (dominant) and 'a'(RECESSIVE), if the frequency of 'A'is P and the frequency of 'a' is q, then the frequencies of the three possible genotypes (AA,Aa and aa) can be expressed by the Hardy-Weinberg equation:
`p^(2)+2pq+q^(2)=1`
where `p^(2)=` FREQEUNCY of A A (HOMOZYGOUS dominant)
Inviduals
`q^(2)=` Frequency of Aa (heterozygous) individuals.
so, p=0.6 and q=0.4 (given)
`therefore 2pq` (frequency of heterozygote) `=2xx0.6xx0.4=0.48`.


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