What is chloride shift?

1.	What is chloride shift?
Answer» A small amount of bicarbonate ions is transported in the erythrocytes (RBCs), whereas most of them diffuse into the blood plasma to be carried by it. Exit of bicarbonate ions, from RBCs considerably change ionic balance between the plasma and the erythrocytes. To restore this ionic balance, the chloride ions diffuse from the plasma into the erythrocytes. This movement of chloride ions is called chloride shift ( = Hamburger’s phenomenon). This process maintains an acid-base equilibrium of pH 7.4 for the blood and electrical balance between erythrocytes and plasma.

Answer»

A small amount of bicarbonate ions is transported in the erythrocytes (RBCs), whereas most of them diffuse into the blood plasma to be carried by it.

Exit of bicarbonate ions, from RBCs considerably change ionic balance between the plasma and the erythrocytes. To restore this ionic balance, the chloride ions diffuse from the plasma into the erythrocytes. This movement of chloride ions is called chloride shift ( = Hamburger’s phenomenon). This process maintains an acid-base equilibrium of pH 7.4 for the blood and electrical balance between erythrocytes and plasma.

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