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What is the principle composition of plasma membrane

Answer» Every living cell is externally covered by a thin transparent electron microscopic, elastic regenerative and selective permeable membrane called plasma membrane. It is quasifluid in nature. Membranes also occur inside the cells. They are collectively called biomembranes. The term cell membrane was given by C. Nageli and C. Cramer (1855) for outer membrane covering of the portoplast. It was replaced by the term plasmalemma by Plower (1931).Chemical composition :\xa0Proteins lipoprotein (Lipid +Protein) are the major component forming 60% of the plasma membrane. Proteins provide mechanical strength and responsible for transportation of different substances. Proteins also act as enzyme. Lipids account may 28%-79% depending upon the type of cell and organism involved (in humans, myelin 79%). The lipids of plasma membrane are of three types namely phospholipids,\xa0glycolipids and sterols. The sterol found in the membrane may be cholesterol (Animals), phytosterol (Plants) or ergosterol (Microorganisms).Carbohydrates form 2%–10%. Oligosaccharides are the main carbohydrates present in plasma membrane. The carbohydrates of plasma membrane are covalently linked to both lipid and protein components.Ultrastructure :\xa0Under electron microscope the plasma membrane appears three layered,\xa0i.e.,\xa0trilaminar or tripartite. One optically light layer is of lipid and on both sides two optically dense protein layers are present.Molecular structure and different models :\xa0Several models have been proposed to explain the structure and function of the plasma membrane.(1)\xa0Overton’s model :\xa0It suggests that the plasma membrane is composed of a thin lipid single layer.(2)\xa0Sandwitch model :\xa0It was proposed by Davson and Danielli (1935). According to this model the light biomolecular lipid layer is sandwitched between two dense protein layers (globular\xa0a\xa0type protein). This model was also said to be unit membrane hypothesis.(3)\xa0Robertson’s unit membrane model :\xa0It states that all cytoplasmic membranes have a similar structure of three layers with and electron transparent phospholipid bilayer being sandwitched between two electron dense layer of proteins (extended or\xa0β type protein).Its thickness is about 75 Å with a central lipid layer of\xa035\xa0AA\xa0thick and two peripheral protein layers of\xa020\xa0AA\xa0thick.(4)\xa0Fluid mosaic model :\xa0The most important and widely accepted latest model for plasma membrane was given by\xa0Singer and Nicolson in\xa01972. According to them it is “protein iceberg in a sea of lipids.”According to this model, the cell membrane consists of a highly viscous fluid matrix of two layers of phospholipid molecules. Protein molecules occur as separate particles asymmetrical arranged in a mosaic pattern.Some of these are loosely bound at the polar surfaces of lipid layers,\xa0called peripheral or extrinsic proteins.\xa0Others penetrate deeply into the lipid layer called integral or intrinsic proteins. Some of the integral proteins penetrate through the phospholipid layers and project on both the surface. These are called trans membrane or tunnel proteins (glycophorins). Singly or in groups, they function as channels for passage of water ions and other solutes.


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