Why does our immune system fail against pathogens like Trypanosoma cru

1.	Why does our immune system fail against pathogens like Trypanosoma cruzi and Plasmodium?
Answer» 1. Microbes have evolved a diverse range of strategies to destroy the host immune system. The protozoan parasite Trypanosoma cruzi and Plasmodium show similar such adaptations to disturb host defence mechanism. 2. This parasite attacks host tissues including both peripheral and central lymphoid tissues. 3. This causes systemic acute response in host body which the parasite tries to overcome. The parasite in fact weakens both innate and acquired immunity. 4. It interferes with the antigen presenting function of dendritic cells via an action on hosts like lectin receptors. These receptors also induce suppression of CD4⁺ T cells responses. Therefore, our immune system fail against such pathogens.

Why does our immune system fail against pathogens like Trypanosoma cruzi and Plasmodium?

Answer»

1. Microbes have evolved a diverse range of strategies to destroy the host immune system. The protozoan parasite Trypanosoma cruzi and Plasmodium show similar such adaptations to disturb host defence mechanism.

2. This parasite attacks host tissues including both peripheral and central lymphoid tissues.

3. This causes systemic acute response in host body which the parasite tries to overcome. The parasite in fact weakens both innate and acquired immunity.

4. It interferes with the antigen presenting function of dendritic cells via an action on hosts like lectin receptors. These receptors also induce suppression of CD4⁺ T cells responses. Therefore, our immune system fail against such pathogens.

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