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A person with 44A + XXY chromosome set up has gynecomastia and is Barr body positive. They are symptoms of

Answer»

Klinefelter’s Syndrome is an aneuploid condition marked by the presence of one or more extra chromosomes in a male (44 + XXY/ 44 + XXXY/ 44 + XXXXY). As we know that, to compensate the dosage of X-linked genes in human male and female, one X-chromosome in females is deactivated and is present as darkly stained body near nuclear envelope. The number of Barr bodies is always one less than the total number of X chromosomes. A human male with Klinefelter’s syndrome, 44 + XXY/ 44 + XXXY/ 44 + XXXXY, can have 1, 2 or 3 Barr bodies, depending on the number of X-chromosome. The presence of extra copy of X-chromosome produces some feminine characters in otherwise male individuals. They are sterile feminised males with enlarged breasts (Gynecomastia).



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