Based on your understanding of genetic code, explain the formation of – InterviewSolution

InterviewSolution

1.	Based on your understanding of genetic code, explain the formation of any abnormal heamoglobin molecule. What are the known consequences of such a change?
Answer» Due to point mutation in `beta`-globin chain of haemoglobin molecule, glutamic acid (Glu) is replaced by valine (Val) at the sixth position. Under stress condition erythrocytes lose their circular shape and become sickle -shaped . As a result, the cells cannot pass through narrow capillaries. Blood capillaries are clogged and thus affect blood supply to different organs.

Discussion

No Comment Found

Related InterviewSolutions

Do you think that the alternate splicing of exons may enable a structural gene to code for several isoproteins from one and the same gene? If yes, how? If not, why so ?
Would it be appropriate to use DNA probes such as VNTR in DNA fingerprinting of a bacteriophage?
Define a cistron. Giving examples differentiate between monocistronic and polycistronic unit.
Give any six features of the human genome.
Retroviruses do not follow central dogma. Comment.
During DNA replication, why is it that the entire molecule does not open in one go? Explain replication fork. What are the two functions that the monomers (dNTPs) play ?
What would happen if histones were to be mutated and made rich in acidic amino acids such as aspertic acid and gultamic acid in place of basic amino acids such as lysine and arginine?
In a nucleus, the number of ribonucleoside triphophates is 10 times the number of deoxy `xx10` ribonucleoside triphosphaes, but only deoxy ribonucleotides are added during the DNA replication. Suggest a mechanism.
Sometimes cattle or even humen beings give birth to their young ones that are having extremely different sets of organs like limba/position of eye(s) etc. Comment .
What is DNA polymorphism? Why is it important to study it?