Colchicine is an alkaloid extracted from plants. It prevents the formation of spindle fibres. In the presence colchicine, if a cell enters mitosis what would be the outcome?

Colchicine is an alkaloid extracted from plants. It prevents the forma

1.	Colchicine is an alkaloid extracted from plants. It prevents the formation of spindle fibres. In the presence colchicine, if a cell enters mitosis what would be the outcome?
Answer» The spindle fibres are necessary for segregating the sister chromatids to opposite poles of the cell during anaphase. In the presence of colchicine, no spindle fibres will form to attach to the kinetochores (small disc¬like structures present on chromosomes). Therefore, the cell will be stuck in mitosis with the condensed pairs of sister chromatids in an unorganized array.