| S.No | Biomicromolecules | Biomacromolecules |
| (i) | Small in size. | Large in size |
| (ii) | Low molecular weight. | High molecular weight |
| (iii) | Possess simple structure. | Possess complex structure. |
| (iv) | Found as molecular solution in intracellular fluid. | Found as colloidal solution in intracellular fluid. |
| (v) | Building blocks (monomers) of macromolecules. | Constituted by polymerization of macromolecules |
| (vi) | E.g., inorganic water compounds (mineral salts, gases), organic compounds (sugars, lipids, nucleotides). | E.g., only organic compounds (polysaccharides, proteins and nucleic acids). |