| Simple epithelium | Compound epithelium |
| 1. It is made up of single layer of cells. | It is made up of two or more layer of cells. |
| 2. Single layer of cells that rest on the basement membrane. | Only lowermost layer rests on basement membrane |
| 3. It is useful in diffusion, osmosis, filtration, secretion and absorption. | Generally protective in function. It has limited role in absorption. |
| 4. It is generally present in the outer and inner lining of organs, blood vessels etc. | It is present in the epidermis of skin, oesophagus, cornea, vagina, rectum, urinary bladder, etc. |