| DNA | RNA |
| 1. Rresent mainly in the chromatin the nucleus. | 1. Most of RNA is present in the cell of cytoplasm (90%) and a little (10%) is the nucleolus |
| 2. Normally double stranded and rarely single stranded. | 2. Normally single stranded and rarely double stranded. |
| 3. It contains deoxyribose suger. | 3. It has ribose sugar |
| 4. It contains bases like Adenine Guanine, cytosine and thymine. | 4. It contains bases like, Adenine Guanine cytosine and uracil. |
| 5. DNA acts as template for its synthesis. | 5. RNA does not act as a template for its synthesis. |