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Explain Griffith’s series of experiments where he witnessed transformation in bacteria he worked with. |
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Answer» Frederick Griffith (1928) conducted experiments with Streptococcus pneumoniae (bacterium causing pneumonia). He observed two strains of this bacterium—one forming smooth shiny colonies (S-type) with capsule, while other forming rough colonies (R-type) without capsule. When live S-type cells were injected into mice, they died due to pneumonia. When live R-type cells were injected into mice, they survived. When heat-killed S-type cells were injected into mice, they survived and there were no symptoms of pneumonia. When heat-killed S-type cells were mixed with live R-type cells and injected into mice, they died due to unexpected symptoms of pneumonia. He concluded that heat-killed S-type bacteria caused a transformation of the R-type bacteria into S-type bacteria but he was not able to understand the cause of this bacterial transformation. |
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