InterviewSolution
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InterviewSolution
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How did he prove that some ‘transforming principle’ is responsible for transformation of the non-virulent strains of bacteria into the virulent form? |
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Answer» Griffith observed two strains of the bacterium—one forming smooth shiny colonies (S-type) with capsule, while other forming rough colonies (R-type) without capsule. He injected live S-type cells into live mice and observed that they died due to pneumonia. He then injected live R-type cells into live mice and observed that they survived. When he injected heat-killed S-type cells into live mice, they survived and there were no symptoms of pnuemonia and when heat-killed S-type cells were mixed with live R-type cells and injected into mice, they died due to unexpected symptoms of pneumonia. He thus, concluded that heat-killed S-type bacteria caused a transformation of the R-type bacteria into S-type bacteria but he was not able to understand the cause of this bacterial transformation. |
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