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How p53 is halting the cell cycle in G1 when DNA is damaged ​

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Answer:

After DNA damage, p53 ACTIVATES the transcription of SEVERAL “downstream” genes, including p21, a gene that belongs to a family of negative cell cycle regulators that INHIBIT Cdk proteins. P21 inactivates most CYCLINS INVOLVED in the cell cycle, and as a result pRB remains underphosphorylated, keeping the cell in G1.

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