1.

i. How does a chromosomal disorder differ from a Mendelian disorder ? ii. Name any two chromosomal aberration associated disorders. iii. List the characteristics of the disorders mentioned above that help in their diagnosis.

Answer»

(i)

S. NoMendelian disorderChromosomal disorder
(i)This disorder is mainly due to alteration or mutation in the single gene.This disorder is caused due to absence or excess or abnormal arrangement of one or more chromosomes.
(ii)This follows Mendel’s principles of inheritanceThis does not follow Mendel’s principles of inheritance.
(iii)This may be recessive or dominant in natureThis is always dominant in nature.
(iv)For example, haemophilia, sickle-cell anaemia.For example, Turner’s syndrome.

ii. Two chromosomal aberration-associated disorders are Down’s syndrome and Klinefelter’s syndrome. 

iii. a. Down’s syndrome: The individuals have overall masculine development but they express feminine development like development of east, i.e., gynaecomastia. They are sterile. 

b. Klinefelter’s syndrome: The females are sterile as ovaries are rudimentary. Other secondary sexual characters are also lacking.


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