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| 1. |
If malonate is present, it inhibits the activity of succinate dehydrogenase. Why is it so? |
| Answer» Malonate is a competitive inhibitor of the enzyme succinate dehydrogenase: malonate binds to the active site of the enzyme without reacting, and so competes with succinate, the usual substrate of the enzyme. The observation that malonate is a competitive inhibitor of succinate dehydrogenase was used to deduce the structure of the active site in that enzyme.The chemical malonate decreases cellular respiration. It resembles the substrate succinate, without a -CH2-CH2 group required for dehydrogenation. | |