In Haldane effect, we say that partial pressure of co2 decreases and that of oxygen increases, so Hb has greater affinity for oxygen, but if co2 is leeaving the lungs, why is it said that oxyhaemoglobin is a strong acid, and an excess of protons are released when we know that this happens only near tissues , when pCO2 increases ? Kindly explain haldane's effect in a simpler way.

In Haldane effect, we say that partial pressure of co2 decreases and t

1.	In Haldane effect, we say that partial pressure of co2 decreases and that of oxygen increases, so Hb has greater affinity for oxygen, but if co2 is leeaving the lungs, why is it said that oxyhaemoglobin is a strong acid, and an excess of protons are released when we know that this happens only near tissues , when pCO2 increases ? Kindly explain haldane's effect in a simpler way.
Answer» In Haldane effect, we say that partial pressure of co2 decreases and that of oxygen increases, so Hb has greater affinity for oxygen, but if co2 is leeaving the lungs, why is it said that oxyhaemoglobin is a strong acid, and an excess of protons are released when we know that this happens only near tissues , when pCO2 increases ? Kindly explain haldane's effect in a simpler way.