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Indicate the inheritance pattern, genomic location and mutation in any two diseases caused by single gene mutations which follow mendelian inheritance. Also, specify the genomic location in any two diseases resulting from gene polymorphisms with complex inheritance. 

Answer»
Single-gene mutations which follow mendelian inheritanceGene polymorphisms which has complex inheritance
Cystic Fibrosis (Cystic Fibrosis Transmembrane Conductance Regulator CFTR gene)
1. Inheritance: autosomal recessive disease
2. Genomic location: Chromosome 7 (7q31.2)
3. Mutation: The most common mutation is a deletion of 3 bps resulting in the loss of codon no. 508, which codes for phenylalanine		Common late-onset Alzheimer's disease
1. Inheritance: Major cause is epsilon4 allele of the gene coding for apolipoproteinE (APOE)
2. Genomic location: Chromosome 19 (19q13) and recently Chromosome 10 (10q21).
Huntington disease (Huntingtin gene HTT)
1. Inheritance: autosomal dominant
2. Location: Chrosome 4 (4p16.3)
3. Mutation: increased number of CAG repeats more than 35 times		Migraine
1. Susceptibility locus: Chromosome 6p12.
2 - 6p21.1 and Chromosome 1q31


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