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in some definitions, it is a general term for the cytoplasm (e.g., Mohl, 1846),[1] but for OTHERS, it also includes the nucleoplasm (e.g., Strasburger, 1882). For Sharp (1921), "According to the older usage the extra-nuclear portion of the protoplast [the entire cell, excluding the cell wall] was called "protoplasm," but the nucleus also is composed of protoplasm, or living substance in its broader sense. The current consensus is to avoid this ambiguity by employing Strasburger's [(1882)] terms cytoplasm [coined by Kölliker (1863), originally as synonym for protoplasm] and nucleoplasm ([term coined by van BENEDEN (1875), or] karyoplasm, [used by] Flemming [(1878)])".[2][3][4][5][6] The cytoplasm definition of Strasburger excluded the plastids (Chromatoplasm).

Like the nucleus, whether to include the vacuole in the protoplasm concept is controversial.[7]

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