Polypeptide chains of two haemoglobin molecules are shown below. One o

1.	Polypeptide chains of two haemoglobin molecules are shown below. One of the chains shows an abnormality. Observe the diagram and answer the following questions.(a) Which of the polypeptide chain in haemoglobin is abnormal leading to a disease?(b) What is the reason for this abnormality? (c) What will be the effect of this change in polypeptide chain?
Answer» (a) A (b) Substitution of glutamic acid by valine in the 6th position of polypeptide chain. (c) The RBC become sickle shaped causing a disease sickle cell anaemia / Affect the o₂ carrying capacity of RBC.

Polypeptide chains of two haemoglobin molecules are shown below. One of the chains shows an abnormality. Observe the diagram and answer the following questions.(a) Which of the polypeptide chain in haemoglobin is abnormal leading to a disease?(b) What is the reason for this abnormality? (c) What will be the effect of this change in polypeptide chain?

Answer»

(a) A

(b) Substitution of glutamic acid by valine in the 6th position of polypeptide chain.