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InterviewSolution
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Question : Give the historical background of DNA. |
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Answer» SOLUTION :DNA as an acidic substance present in nucleus was first identified by Friedrich Meischer in 1869. He named it as .Nuclein.. Due to technical limitation in isolating such a long polymer intact the elucidation of structure of DNA remained elusive for a very long period of TIME. It was only in 1953 that James Watson and Francis Crick, based on the X-ray diffraction data produced by Maurice Wilkins and ROSALIND Franklin proposed a very simple but famous Double Helix model for the structure of DNA. One of the hallmarks of their proposition was ALSO based on the observation of Erwin Chargaff that for a double stranded DNA the ratio between Adenine and Thymine and Guanine and cytosine are constant and equals one. |
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