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Question : How is a polypeptide chain synthesis terminated during protein synthesis?

Answer»

Solution :Synthesis of polypeptide chain terminates when a nonsense codon of mRNA reaches the A-site. There are three nonsense codon UAA, UAG and UGA, which are not recognized by any of the tRNAs. Therefore no more amino-acyl TRNA reaches the A site. The P site t-RNAs is hydrolysed and the completed polypeptide is RELEASED in the presence of GTP DEPENDENT release factor.


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