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Question : Lipopolysaccharides of gram-negative bacteria acts as endotoxin and has pyrogen effect for human. Few nanograms of pyrogen can cause very high fever. This stimulates macrophages and neutrophils to secrete IL-1 beta, TNF -alpha and IL-6 that act on the hypothalamus to produce fever. Fever forms ...... barrier of innate immunity :-

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Physiological
Physical
Cellular
Cytokine

Answer :A


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