Question : What are recombinant DNA vaccines? Give two examples of such vaccines. Discusstheir advantages.

Question : What are recombinant DNA vaccines? Give two examples of suc

1.	Question : What are recombinant DNA vaccines? Give two examples of such vaccines. Discusstheir advantages.
Answer» SOLUTION :Recombinant DNA vaccinesare made up of a small circularDNA (plasmid)that has very tiny piece of pathogen DNA incorporatedin it to produce one or two specificproteinsof the pathogen. This recombinantDNA is introducedin to the bacteria or yeast cells, where it can USE cell's machinery to produce polypeptidesof pathogen. These are used as vaccine to trigger a range of immune responses. Vaccines produced by using this approachallow large scale PRODUCTION. e.g., (i) Hepatitis-B vaccine produced from yeast . (ii) Bird flu DNA vaccine. Advantages (i) RecombinantDNA vaccines are advantageousover killed or attenuatedvaccines since, they does not get virulentor mutated again as it is seen in CASE of attenuatedvaccines. (ii) Secondlythese are highly pure, specificand elicitsstrong immune response.