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Question : What is RNA interference ? |
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Answer» Solution :RNA interference is a biological process in which RNA molecules inhibit gene expression or translation . This is done by neutralising targeted MRNA molecules. A simplified model for the RNAI pathway is based o two steps, each involving RIBONUCLEASE enzyme . In the first step , the trigger RNA (either dsRNA or miRNA primary transcript ) is processed into a short interfering RNA (siRNA) by the RNase II enzymes called Dicer and Drosha . In the SECOND step , siRNAs are loaded into the effectors complex RNA - INDUCED silencing complex (RISC) . The siRNA is unwound during RISC assembly and the single - stranded RNA hybridiezed with mRNA target . This RNAi is seen in plant feeding nematodes. |
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