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Regarding the effective half-life of a radionuclide: a. It takes into account the biological and physical half-lives b. It decreases as a result of renal failure c. The dose received by an organ is proportional to the effective half-life d. It differs among individuals for a given radio pharmaceutical e. It is generally increased in patients with liver failure |
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Answer» a. True. The effective half-life is calculated from both the biological and physical half-lives. b. False. The effective half-life may not depend on renal excretion e.g. Kr-81m, and, even if it does, renal failure results in an increased biological half-life and therefore an increased effective half-life. c. True. The dose to an organ increases in proportion to the effective half-life. d. True. This is mainly due to the fact that the biological half-life varies among individuals according to their disease state and physiological factors. e. False. This will only be the case in those radio pharmaceuticals that are excreted by the biliary system. |
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