1.

S_(N^2) reaction of an optically active haloalkane is accompanied by inversion of configuration at the asymmetric centre. Prove it.

Answer»

SOLUTION :(i) `S_(N^2)`reaction of an optically active haloalkane (e.g., 2-bromo-octane) is accompanied by inversion of configuration at the ASYMMETRIC centre.
(ii) When 2-bromooctane is heated with sodium hydroxide, 2-octanol is formed with inversion of configuration. (-) 2-bromo-octane on heating with sodium hydroxide gives (+) 2-octanol is formed in which-OH GROUP occupies a position opposite to what BROMINE had OCCUPIED in the optically active haloalkane.


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