Scenario: A 68-year-old Woman With A History Of Heavy Tobacco Use Is

1.	Scenario: A 68-year-old Woman With A History Of Heavy Tobacco Use Is Found To Have A Solitary Lung Nodule On Chest Computed Tomography. Pathology From A Recent Bronchoscopy Reveals Adenocarcinoma. What Further Staging Work-up Is Necessary For This Patient Before Surgical Resection?
Answer» FDG([18F]2-Fluoro-2-deoxy-glucose)-PET for baseline locoregional staging is now part of the standard work-up for non-small cell lung cancer (NSCLC). The true strength of this test for the mediastinum is its negative predictive value (NPV) when FDG uptake in the primary tumor is sufficient and a CENTRAL tumor or important hilar LYMPH node disease is absent. Two well-designed, prospective studies confirmed the HIGH NPV (98%) of the mediastinum of PATIENTS with resectable NSCLC and that significantly fewer invasive tests (ie, mediastinoscopy) were required in the PET group than in the traditional work-up group. FDG([18F]2-Fluoro-2-deoxy-glucose)-PET for baseline locoregional staging is now part of the standard work-up for non-small cell lung cancer (NSCLC). The true strength of this test for the mediastinum is its negative predictive value (NPV) when FDG uptake in the primary tumor is sufficient and a central tumor or important hilar lymph node disease is absent. Two well-designed, prospective studies confirmed the high NPV (98%) of the mediastinum of patients with resectable NSCLC and that significantly fewer invasive tests (ie, mediastinoscopy) were required in the PET group than in the traditional work-up group.

Scenario: A 68-year-old Woman With A History Of Heavy Tobacco Use Is Found To Have A Solitary Lung Nodule On Chest Computed Tomography. Pathology From A Recent Bronchoscopy Reveals Adenocarcinoma. What Further Staging Work-up Is Necessary For This Patient Before Surgical Resection?

Answer»

FDG([18F]2-Fluoro-2-deoxy-glucose)-PET for baseline locoregional staging is now part of the standard work-up for non-small cell lung cancer (NSCLC). The true strength of this test for the mediastinum is its negative predictive value (NPV) when FDG uptake in the primary tumor is sufficient and a CENTRAL tumor or important hilar LYMPH node disease is absent. Two well-designed, prospective studies confirmed the HIGH NPV (98%) of the mediastinum of PATIENTS with resectable NSCLC and that significantly fewer invasive tests (ie, mediastinoscopy) were required in the PET group than in the traditional work-up group.

FDG([18F]2-Fluoro-2-deoxy-glucose)-PET for baseline locoregional staging is now part of the standard work-up for non-small cell lung cancer (NSCLC). The true strength of this test for the mediastinum is its negative predictive value (NPV) when FDG uptake in the primary tumor is sufficient and a central tumor or important hilar lymph node disease is absent. Two well-designed, prospective studies confirmed the high NPV (98%) of the mediastinum of patients with resectable NSCLC and that significantly fewer invasive tests (ie, mediastinoscopy) were required in the PET group than in the traditional work-up group.

Scenario: A 68-year-old Woman With A History Of Heavy Tobacco Use Is Found To Have A Solitary Lung Nodule On Chest Computed Tomography. Pathology From A Recent Bronchoscopy Reveals Adenocarcinoma. What Further Staging Work-up Is Necessary For This Patient Before Surgical Resection?

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