This will be a lengthy post. I want to make sure I specify as much as I can. First I'll explain the issue, then I'll explain the almost comical number of things I've done to try and fix it, and then I'll list off my specs. I really hope someone can help me solve this... it's been more than a year since this issue started!

The Problem

My video will occasionally freak out, usually when I'm seeing a video or an animated/ video advertisement, especially on Facebook, YouTube, or Politico. The screen will go nuts, flashing like a strobe light, and the image will be scattered all over the place. Sounds pretty straight-forward, right? Well, it's not.

Also, probably unrelated, but my mouse won't stay zoomed in shooter games, like BF3, BF4, Fallout NV, and some others. I'll right-click and hold, but it zooms in and back out and won't stay steady. It's super annoying, but not as bad as having to hard-reboot my machine every few hours because the screen goes nuts, so I figured I would address that later in a different thread, but MAYBE it's related? I don't know.

What I've tried

Here's a list of all the things I've tried, in the exact order I tried them in. None of these things worked. It's QUITE frustrating!:

- Tested on another monitor, with a different HDMI cable
- Tested on that other monitor with a DVI cable
- Tested on an LED TV with a different HDMI cable
- Hard-limit the refresh rate to 75
- Hard-limit the refresh rate to 60
- Uninstall and reinstall the video card driver
- Update the video card firmware
- Completely wipe my SSD and reinstall Windows 7
- Tried wiping the SSD and reinstalling the OS again, because why not

(This is the part where I started getting angry and throwing money at it)

- Replaced my Sapphire HD 6950 with an XFX R9-280X
- Replaced my PSU (upgrade from 600w to 1000w)
- Replaced my motherboard
- Bought a new 256 GB SSD to replace the old one (the old one is still in the system, as game storage)
- Upgraded to Windows 10

I'm at the point where I feel like I've exhausted nearly every OPTION, and spent a small fortune in the process. The only options I have left are either replacing my CPU or my RAM, neither of which really need an upgrade right now (or for another two years probably). What the heck am I missing?! What could this possibly be? Is it software? Firmware? Hardware? I don't want to replace the CPU just to learn it was the RAM, or vice-versa, you know?

My Specs:
(I'm including literally everything, right down to the peripherals, because why the heck not. It could be anything at this point, so I don't want to leave any stone unturned!)

Case (probably irrelevant): Corsair C70
PSU: Raidmax RX1000AE (formerly a Corsair 600w)
Mobo: Asus Sabertooth 990FX r2.0 (formerly an ASRock 990FX Extreme4)
CPU: AMD FX-8150
RAM: 16 GB G.Skill Sniper Series 1866
Video Card: XFX R9-280x Double-D (formerly a Sapphire HD 6950 OC edition)
Storage 1: 256 GB Crucial M4 SSD (OS, some games)
Storage 2: 256 GB Kingston SSD (games)
Storage 3: 2 TB WD Black HDD (games, nonessential software)
Storage 4: 2 TB WD Green HDD (work stuff, documents, photos, music, nonsense)
Storage 5: 2 TB WD External HDD (backups)
OS: Windows 10 64-bit home premium

And a bunch of other (probably irrelevant) stuff:
Monitor: 27" Acer LED @ 1080P, currently unlimited (probably 75 Hz)
Keyboard: Logitech G510
Mouse: Logitech G500
Stick: X52
Printer: Epson XP-410

Edit: Worth noting I just rebuilt the machine again when I upgraded my PC case last week, so everything is seated properly. I checked over and over, like when you think your left your keys on the coffee table so you keep looking there repeatedly, lol.

Have you run memtest86 for about 3 passes to make sure the flickering isnt being caused my a memory issue?

You went through great efforts to narrow it down. Hopefully we can suggest some things to do that doesnt cost you any more money.I tried four memtests to date, two in one day and two the following day, this past summer. I forgot to mention that. But it all came back with good results. I was hoping it was the RAM because G.Skill has a lifetime warranty. But I don't want to write off the RAM in case this is maybe some other RAM issue I'm not knowledgeable enough to recognize.Does the computer work in a different location?
Like in another building? Or across town?
Do other computers work in the same location?

I haven't tried it in a different building, but both my girlfriend's PC and our living room PC work fine. Also, my old computer works fine, and friends have used laptops here without issues. We don't live near heavy power lines or anything industrial that might cause interference. If it's an interference issue it would need to be something related specifically to this machine, but all that's really original in it today is the RAM, CPU, and sound card (I've replaced everything else since the problem began).