1.

Suppose a person is suffering from calcium deficiency for a prolonged time. How does it affect muscular contraction?

Answer»

Muscle contraction begins when a nerve impulse reaches at the neuromuscular junction. During this time the sarcoplasmic reticulum releases Ca2+ . The Ca2+ binds with the specific site of the troponin of the actin filament.

This causes a conformational change in the troponin molecule and expose the active site on the actin molecule. Myosin lament binds with the active site of actin and there is formation a cross bridge. By the movement of cross bridge contraction occurs.

The contraction is followed by relaxation and it occurs when Ca2+ in pumped back into the sarcoplasmic reticulum. As a result, the troponin molecules became free to mask the active site of the myosin head.



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