..Acromegaly. Sometimes the pituitary gland makes too much growth HORMONE and your bones get bigger. It usually affects your hands, feet, and face...Cushing's disease. In this, your body makes too much cortisol. You could gain weight, get stretch MARKS, bruise easily at first, then get weakened muscles and bones and possibly develop a hump on your upper back.Hyperthyroidism. This is when your THYROID gland makes more hormones than your body needs. You MIGHT hear it CALLED overactive thyroid. It makes your system run fast and you might feel nervous, lose weight, and have a rapid heartbeat or trouble sleeping.Hypothyroidism. When your body doesn’t make enough thyroid hormone, your system slows down. You might feel tired, gain weight, have a slow heartbeat, and get joint and muscle pains.Adrenal insufficiency. When you have this, your adrenal glands don’t make enough of certain hormones, like cortisol, which controls stress.Multiple endocrine neoplasia. This is a group of disorders that affect your endocrine system. It causes tumors on at least two endocrine glands or in other organs and tissues...Polycystic ovary syndrome. An imbalance of reproductive hormones can cause your ovaries to either not make an egg or not release it during ovulation. This can throw off your periods, cause acne, and make hair to grow on your face or chin...