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The major disadvantage of cosmids is(a) inability to accept more than 40 - 50 kbp of DNA(b) allow the packaging of DNA in phage in vitro(c) also perpetuate in bacteria(d) can produce a complete genome library of 108

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Answer is : (a) inability to accept more than 40 - 50 kbp of DNA

The major disadvantage of cosmids is their inability to accept more than 40 - 50 kbp of DNA. Cosmids are the vectors, which can accommodate DNA segments upto 45 kbp.



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