AccommodationsGetting a good place(affordable, secure and close to workplace) to stay has become increasingly difficult over the years. The major factors are lack of good housing in all major cities, high rental costs, traffic issues, perception about migrants within the local community. If you are a bachelor or a spinster things me be more difficult for you. In cities like Pune, Bangalore and Hyderabad many of the larger housing societies restricts home owners to let their houses/flats to unmarried people. This has led to others charging mercurial rents and unmarried people being pushed out to the fringe locationsLanguageIf you are moving to a city which doesn't speak the same language as you do, things may get tough. With no hard feelings, cities in TN and Kerala pose the biggest challenge while places like Bangalore, Pune, Hyderabad, Ahmedabad, Kolkata etc. are manageable.Local Transportation/conveyanceEach city in India has its own model of public transport. The auto-rickshaw drivers in each city have their own set of unsaid rules. You may take time to understand these and come to terms with each and every quirk presented to you. The language factor place a big role here. A lot of cities in southern India and Maharashtra do not have bus numbers/routes written in English. Route number is the only key that you can use to identify where the bus is going. This may take you time to get familiar with.Food habitsA nation as big as India is destined to have varied food habits across the geography. If you are not a foodie who loves all kinds of food and are moving to a completely different part of the country, you may face this issue. Although these days all major cities in India provide all major kind of cuisines but still you may face this challenge.Longing/NostalgiaAfter living for a long time in one city and then moving to another will be accompanied with moments of nostalgia. This would be frequent initially but will weather away with time. If you are move out from your home town this would be particularly acute. But this is something completely natural and should not be ignored. The easiest cure for this problem is to pick up the phone and call your friends/family. Or if you are close enough, just catch the bus/train/flight over the weekend and come back afresh