1.

The pK_(a) of acetylsalicylic acid (aspirin) is 3.5. The pH of gastric juice in human stomach is about 2-3 and the pH in the small intestine is about 8. Aspirine will be

Answer»

Unionised in the small intestineand the STOMACH
Completely ionised in the small INTESTINE and in the stomach
Ionised in the stomach and ALMOST unionised in the small intestine
Ionised in the small intestine and almost unionised in the stomach

Solution :Under strong acidic conditions present in stomach (pH 2-3), weak acids such as acetylsalicylic ACID with `pK_(a) = 3.5` remains unionized but under basic conditions (pH 8) present in small intestine, it is ionized. Thus option (d) is correct.


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