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InterviewSolution
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The `pK_(a)` of acetylsalicylic acid (aspirin) is 3.5. The pH of gastric juice in human stomach is about `2-3` and pH in the small intestine is about 8. Aspirin will beA. Unionized in the small intestine and in the stomachB. Completely ionized in the stomach and almost unionized in the small intestineC. Ionised in the stomach and almost unionized in the small intestineD. Ionised in the small intestine and almost unionized in the stomach |
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Answer» Correct Answer - D The pH of gastric juice in humar stomach is about 2-3 (highly acidic) acetyl salicylic acid is a weak acid, as such its ionisation will be supressed in the presencce of a strong acid. Thus it will be weak acid, as such its ionisation will be suppressed in the presence of a strong acid. The `pH` in the small intestine is about 8 i.e, slightly basic as such ionisatation of aspirin will increase in small intestine. Thus it will be more ionised in small intestine |
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