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The `pK_(a)` of acetylsalicylic acid (aspirin) is 3.5. The pH of gastric juice in human stomach is about 2-3 and the pH in the small intestine is about 8. Aspirine will beA. Unionised in the small intestine and the stomachB. Completely ionised in the small intestine and in the stomachC. Ionised in the stomach and almost unionised in the small intestineD. Ionised in the small intestine and almost unionised in the stomach |
Answer» Correct Answer - D Under strong acidic conditions present in stomach (pH 2-3), weak acids such as acetylsalicylic acid with `pK_(a) = 3.5` remains unionized but under basic conditions (pH 8) present in small intestine, it is ionized. Thus option (d) is correct. |
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