What Are The Main Differences Between High Performance Liquid Chromat

1.	What Are The Main Differences Between High Performance Liquid Chromatography And Gas Chromatography?
Answer» In HPLC the mobile phase is a liquid whereas in Gas Chromatography the mobile phase or carrier is a gas. HPLC is useful for analysis of SAMPLES which are liable to decompose at higher temperatures. GC INVOLVES high temperatures so compounds are stable at such temperatures. Gas Chromatography is applied for analysis of volatile compounds whereas non volatile compounds can be easily analyzed on HPLC Gas Chromatography cannot be used for analysis of high molecular weight molecules whereas HPLC has applications for separation and identification of very high molecular weight compounds HPLC REQUIRES higher OPERATING pressures than GC because liquids require higher pressures than gases for transport through the SYSTEM HPLC columns are short and wide in comparison to GC columns

What Are The Main Differences Between High Performance Liquid Chromatography And Gas Chromatography?

Answer»

In HPLC the mobile phase is a liquid whereas in Gas Chromatography the mobile phase or carrier is a gas.
HPLC is useful for analysis of SAMPLES which are liable to decompose at higher temperatures. GC INVOLVES high temperatures so compounds are stable at such temperatures.
Gas Chromatography is applied for analysis of volatile compounds whereas non volatile compounds can be easily analyzed on HPLC
Gas Chromatography cannot be used for analysis of high molecular weight molecules whereas HPLC has applications for separation and identification of very high molecular weight compounds
HPLC REQUIRES higher OPERATING pressures than GC because liquids require higher pressures than gases for transport through the SYSTEM
HPLC columns are short and wide in comparison to GC columns