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                                    What is cause of itai itai disease ? | 
                            
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Answer»  Itai-itai disease is CAUSED by cadmium (Cd) EXPOSURE, produced as a result of human activities related to industrialisation, and this condition was FIRST recognised in Japan in the 1960s. 1 2. Itai-itai disease is characterised by osteomalaecia with severe BONE pain and is associated with renal tubular dysfunction. Explanation: follow me like my answer  | 
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