InterviewSolution
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InterviewSolution
| 1. |
What is the function of G2 phase? |
| Answer» G2 phase, or Gap 2 phase, is the second subphase of Interphase in the cell cycle directly preceding mitosis. It follows the successful completion of S phase, during which the cell’s DNA is replicated.G2 phase ends with the onset of prophase, the first phase of mitosis in which the cell’s chromatin condenses into chromosomes. G2 phase is a period of rapid cells growth and protein synthesis during which the cell prepares itself for mitosisExposure of mammalian cells to X rays results in prolongation of the cell cycle, including delays or arrests in G1, S and G2 phase. While G1-phase arrest occurs only in cells with wild-type p53 function, a G2-phase delay occurs in all cells regardless of p53 status. In this review, we summarize what is known about cell cycle progression through G2 and M phase and discuss the experimental findings that implicate different mechanisms in the G2-phase delay. Finally, we consider the possibility that G2-phase arrest plays a role in cell survival after irradiation. | |