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What Percentage Of All Breast Cancer Cases Is Related To Genetic Susceptibility? |
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Answer» Genetic susceptibility to breast cancer accounts for approximately 25% of all breast cancer cases. In FAMILIAL breast cancer, mutations in the BRCA1, BRCA2, CHEK2, TP53, and PTEN genes account for approximately 5% to 10% of breast and OVARIAN cancer cases overall. The prevalence of BRCA1 or BRCA2 mutations varies considerably among ETHNIC groups and geographical areas. In NORTH America, 1 in EVERY 300 to 500 people is estimated to harbor BRCA germline mutations. Genetic susceptibility to breast cancer accounts for approximately 25% of all breast cancer cases. In familial breast cancer, mutations in the BRCA1, BRCA2, CHEK2, TP53, and PTEN genes account for approximately 5% to 10% of breast and ovarian cancer cases overall. The prevalence of BRCA1 or BRCA2 mutations varies considerably among ethnic groups and geographical areas. In North America, 1 in every 300 to 500 people is estimated to harbor BRCA germline mutations. |
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