1.

What transports unconjugated bilirubin to liver

Answer»
  • At the sinusoidal surface of the liver, unconjugated bilirubin detaches from albumin and is transported through the hepatocyte membrane by facilitated diffusion.
  • In order for bilirubin to be excreted into bile and, therefore, eliminated from the body, it must be made more soluble.
  • Hepatocytes have a selective and highly efficient system for removing unconjugated bilirubin from plasma.
  • In the hepatocyte, the transported bilirubin is bound to ligandin, a cytosolic protein, that facilitates transfer to the endoplasmic reticulum, the site of bilirubin conjugation.


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