When a nucleophile attach te carbonyl group of a carboxylic acid deriative, the carbon-oxygen pi- bond breaks. The resulting intermediate is called a tetrahedral inntermediuate because sp^(2) carbon in the reactant has become a tetrahedral (sp^(3)) carbon in the intermediate. Here overset(..)Y^(ɵ) is leaving gourp, the weaker base is expelled preferentially. Q. Which of the following given compounds dot't form amide, when react with CH_(3)COCl. (1). CH_(3)-NH-CH_(3) (2). CH_(3)-underset(CH_(3))underset(|)N-CH_(2)H_(5) (3). (4). CH_(3)-CH_(2)-CH_(2)-NH_(2)

When a nucleophile attach te carbonyl group of a carboxylic acid der

1.	When a nucleophile attach te carbonyl group of a carboxylic acid deriative, the carbon-oxygen pi- bond breaks. The resulting intermediate is called a tetrahedral inntermediuate because sp^(2) carbon in the reactant has become a tetrahedral (sp^(3)) carbon in the intermediate. Here overset(..)Y^(ɵ) is leaving gourp, the weaker base is expelled preferentially. Q. Which of the following given compounds dot't form amide, when react with CH_(3)COCl. (1). CH_(3)-NH-CH_(3) (2). CH_(3)-underset(CH_(3))underset(\|)N-CH_(2)H_(5) (3). (4). CH_(3)-CH_(2)-CH_(2)-NH_(2)
Answer» (1 and 4) only (4) (2 and 3) only (1) SOLUTION :TERTIARY amine and PYRIDINE doesn't from amides when react with `CH_(3)-underset(O)underset(\|\|)C-Cl`