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Which of the following are true regarding the biological half-life of a radio pharmaceutical? a. It is dependent on the rate of radioactive decay of the radio pharmaceutical within the body b. It may increase as a result of organ failure c. It is used to calculate the effective half-life d. It is shorter than the effective half-life e. It is the same for a given radio pharmaceutical in every individual |
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Answer» a. False. Biological half-life is dependent on the rate of elimination of the radio pharmaceutical from the body. b. True. A radio pharmaceutical is eliminated from the body by organ-dependent processes such as metabolism (liver) and excretion (kidneys). c. True. 1/effective half-life = 1/physical half-life þ 1/biological half-life. d. False. The effective half-life is shorter than the biological or physical half-life. e. False. The biological half-life is dependent on the pharmaceutical agent used, as well as patient factors (e.g. disease process, renal failure) and therefore differs among individuals. |
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