InterviewSolution
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InterviewSolution
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Which Of The Following Targeted Agents Is Not A Tyrosine Kinase Inhibitor That Influences The Human Epidermal Growth Factor Receptor (her) Family Signaling Pathway By Binding To The Intracellular Domain Of The Receptors? |
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Answer» TYROSINE kinase inhibitors, such as gefitinib and erlotinib (HER1 inhibitors) and lapatinib (a HER1/HER2 INHIBITOR), influence the signaling pathway by interacting with the intracellular domain of the receptors of HER1 and HER2. Trastuzumab is a humanized monoclonal antibody that targets the EXTRACELLULAR domain of the HER2 receptor to prevent dimerization with other HER FAMILY MEMBERS and subsequent downstream signaling events. Tyrosine kinase inhibitors, such as gefitinib and erlotinib (HER1 inhibitors) and lapatinib (a HER1/HER2 inhibitor), influence the signaling pathway by interacting with the intracellular domain of the receptors of HER1 and HER2. Trastuzumab is a humanized monoclonal antibody that targets the extracellular domain of the HER2 receptor to prevent dimerization with other HER family members and subsequent downstream signaling events. |
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