1.

Why is it not possible for an alien DNA to become part of a chromosome anywhere along its length and replicate normally?

Answer» The original of replication (ori) is the only site on the plasmid where intiaiton of DNA replication takes place. Therefore binding foreign DNA to the ori will incorporate it into the plasmid thereby becoming replicable.

Alien DNA must be linked to ori or origin of replication site to start replication.



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