InterviewSolution
Saved Bookmarks
InterviewSolution
| 1. |
Why ketone does not exhibit in Electrophillic substitution Rxn? |
| Answer» <p>Because carbonyl groups are strongly polarized: partially positive at the carbon end, partially negative at the oxygen end.</p><p>The result is that the oxygen end is a (rather weak) Bronsted base, while the carbon end is attractive to nucleophiles.</p><p>You should notice that only anionic nucleophiles add to neutral carbonyl groups, because the product of addition is a negative charge on oxygen.</p><p>In order to add a neutral nucleophile, you need to protonate the oxygen first.</p> | |