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Write short note on :Erythroblastosis foetalis. |
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Answer» 1. Erythroblastosis foetalis is condition in which there is destruction of the erythrocytes of the foetus. It is the haemolytic disease of the newborn (HDN). 2. This is caused in foetus, if mother is Rh -ve and father is Rh +ve. Rh +ve is the dominant allele, the foetus becomes Rh +ve, when its father is RH +ve. 3. Rh +ve blood groups have D antigen which induces a strong immunogenic response when introduced into Rh -ve individuals. 4. During foetal life, there is connection between mother and foetus through placenta, therefore Rh +ve antigen D from the foetus enters maternal circulation. 5. This triggers formation of anti-Rh antibodies in mother. Subsequently Rh+ve foetus receives anti-Rh antibodies produced by mother. 6. This causes agglutination reaction resulting into haemolysis in foetus. In order to prevent HDN, Rh -ve mother is injected with the anti-Rh antibody during all her pregnancies if her husband is Rh +ve. |
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