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Write the type and location of the gene causing thalassaemia in humans. State the cause and symptoms of the disease. How is sickle cell anaemia different from this disease? |
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Answer» (i) Autosomal, recessive gene, gene for alpha thalassemia is on chromosome 16, for Beta thalassemia it is on chromosome 11. (ii) Cause of symptoms-Mutation or deletion of the gene / genes, resulting in reduced rate of synthesis of one of the globin chains / alpha or beta chains. (iii) Thalassaemia is a quantitative problem/ of too few globin molecules of haemoglobin, while sicklecell is a qualitative problem of synthesizing an incorrectly functioning globin. |
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