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51.

The sporic or intermediate meiosis is unrelated to gamete formation.(a) True(b) FalseThis question was posed to me in an international level competition.This key question is from Cellular Reproduction in section DNA Replication and Repair, Cellular Reproduction of Cell Biology

Answer»

The correct option is (a) True

Easy explanation: The sporic or intermediate meiosis occurs in plants and some algae. In these organisms, the meiotic division TAKES place at a stage unrelated to either gamete formation or fertilization. SPOROGENESIS (that INCLUDES meiosis) occurs producing spores that GERMINATE into SPOROPHYTES.

52.

Which is the last phase in mitosis just before the beginning of cytokinesis?(a) telophase(b) metaphase(c) interphase(d) prometaphaseThe question was posed to me in an online quiz.I'm obligated to ask this question of Cellular Reproduction in chapter DNA Replication and Repair, Cellular Reproduction of Cell Biology

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The correct choice is (a) telophase

To explain: The last phase in mitosis, just before the onset of cytokinesis is the telophase. During this phase CHROMOSOMES CLUSTER at opposite SPINDLE POLES and the daughter cells FORM by cytokinesis.

53.

The entry of a cell into M phase is initiated by _________________(a) interleukin factor(b) maturation promoting factor(c) transcription factor(d) necrosis factorI have been asked this question by my school principal while I was bunking the class.This question is from Cellular Reproduction in portion DNA Replication and Repair, Cellular Reproduction of Cell Biology

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The correct choice is (b) maturation promoting FACTOR

The explanation is: The entry of a CELL into mitotic (division or M phase) phase is initiated by the maturation promoting factor (MPF). It CONSISTS of TWO subunits – one with kinase ACTIVITY and the other with regulatory activity.

54.

Which of the following enzyme is responsible for initiating DNA replication?(a) polymerase(b) ligase(c) primase(d) gyraseThe question was asked during a job interview.Origin of the question is DNA Replication in chapter DNA Replication and Repair, Cellular Reproduction of Cell Biology

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Correct answer is (c) primase

The best explanation: The enzyme primase is a type of RNA polymerase that is RESPONSIBLE for initiating DNA replication. This enzyme constructs a short primer composed of RNA, that SERVE as PRIMERS for the SYNTHESIS of DNA by DNA polymerase.

55.

Chromosome compaction at prophase requires ______________________(a) DNA helicase(b) DNA polymerase(c) RNA polymerase(d) Topoisomerase IIThe question was asked in my homework.This is a very interesting question from Cellular Reproduction in portion DNA Replication and Repair, Cellular Reproduction of Cell Biology

Answer» CORRECT CHOICE is (d) Topoisomerase II

The best I can EXPLAIN: Chromosome compaction at PROPHASE requires topoisomerase II which is present as a part of mitotic chromosome SCAFFOLD along with the multiprotein complex condensing.
56.

Centromeres split during the __________________(a) translation(b) transcription(c) anaphase(d) prometaphaseThe question was posed to me in quiz.Query is from Cellular Reproduction topic in division DNA Replication and Repair, Cellular Reproduction of Cell Biology

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Correct option is (c) anaphase

To elaborate: Centromeres are the junction where two sister CHROMATIDS are JOINED. In the anaphase of mitosis, the centromeres SPLIT and chromatids separate and the CHROMOSOMES MOVE to opposite poles.

57.

Mitosis is the process of segregation of DNA molecules into 2 cells.(a) True(b) FalseThe question was asked during an interview.The question is from Cellular Reproduction topic in division DNA Replication and Repair, Cellular Reproduction of Cell Biology

Answer» CORRECT choice is (a) True

The explanation is: MITOSIS is the process of nuclear division in which the replicated DNA MOLECULES are segregated into two nuclei. The nuclei then END up in two ORIGINATING daughter cells.
58.

There are ______ major phases in a cell cycle.(a) 1(b) 2(c) 3(d) 4This question was posed to me in examination.My question is based upon Cellular Reproduction in chapter DNA Replication and Repair, Cellular Reproduction of Cell Biology

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The CORRECT option is (B) 2

To explain I WOULD SAY: Cells in vivo and in vitro pass through a SERIES of defined stages, constituting the cell cycle. The two major phases of the cell cycle are M phase (constituting mitosis and cytokinesis) and interphase.

59.

Which if the following polymerases have an unusually spacious active site?(a) DNA polymerases(b) TLS polymerases(c) RNA polymerases(d) DNA helicasesI got this question in homework.This interesting question is from Between Replication and Repair in section DNA Replication and Repair, Cellular Reproduction of Cell Biology

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The correct option is (b) TLS polymerases

The explanation: Translesion synthesis (TLS) polymerases have an UNUSUALLY spacious active SITE for ACCOMMODATING altered nucleotides that would not fit in other replicative ENZYMES.

60.

Which repair system operates to remove the altered bases generated by reactive chemicals present in the diet?(a) Base excision repair(b) Nucleotide excision repair(c) Mismatch repair(d) Double-stranded breakage repairI got this question in an interview.My question is based upon DNA Repair topic in division DNA Replication and Repair, Cellular Reproduction of Cell Biology

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Correct CHOICE is (a) Base excision repair

The explanation is: Base excision repair SYSTEM (BER) operates to remove or RECTIFY the altered nucleotides generated as a result of action of REACTIVE chemicals presented in the diet or generated by the metabolism.

61.

When was DNA polymerase III discovered as the major enzyme behind DNA replication in bacteria?(a) 1949(b) 1959(c) 1969(d) 1989This question was posed to me in an interview.I'm obligated to ask this question of DNA Replication topic in division DNA Replication and Repair, Cellular Reproduction of Cell Biology

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Right option is (c) 1969

Best explanation: In 1960s, there were HINTS that Kornberg enzyme – DNA polymerase I was not the only polymerase in a BACTERIAL CELL. In 1969, it CAME to be known that the major enzyme behind DNA replication is DNA polymerase III.

62.

The absence of second X chromosome in a female leads to _______________________(a) Down syndrome(b) Turner syndrome(c) Alzheimer’s disease(d) LeukemiaThis question was addressed to me by my college director while I was bunking the class.I need to ask this question from Cellular Reproduction in division DNA Replication and Repair, Cellular Reproduction of Cell Biology

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The correct choice is (b) TURNER syndrome

The best I can explain: The ABSENCE of a SECOND sex CHROMOSOME (denoted XO) develops into a female with Turner Syndrome. The Turner syndrome is characterized by GENITAL impairment and abnormal body structure.

63.

DNA replication can be monitored by incorporation of ______________________(a) tyrosine(b) thymidine(c) cytosine(d) nititeThis question was addressed to me at a job interview.The question is from Cellular Reproduction in section DNA Replication and Repair, Cellular Reproduction of Cell Biology

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Correct choice is (b) thymidine

Explanation: DNA replication can be MONITORED by incorporating [^3H]thymidine in the STRANDS of DOUBLE HELIX. In this way, microscopy can be used to illustrate how the cells PASS through each stage of the cell cycle.

64.

Xeroderma pigmentosum is caused by ______________________(a) UV radiations(b) X-rays(c) Gamma radiations(d) Beta-raysI have been asked this question at a job interview.The origin of the question is DNA Repair topic in section DNA Replication and Repair, Cellular Reproduction of Cell Biology

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The correct answer is (a) UV radiations

To explain: Xeroderma pigmentosum (XP) is a rare genetic DISORDER due to DEFICIENCY in nucleotide EXCISION repair system that cannot remove segments of DNA DAMAGED by ultraviolet radiations.

65.

A mismatched base pair can cause ________________ in the double helix.(a) change in geometry(b) change in location(c) change in size(d) change in alkalinityThe question was asked in an online interview.The above asked question is from DNA Repair topic in section DNA Replication and Repair, Cellular Reproduction of Cell Biology

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Correct answer is (a) CHANGE in geometry

Explanation: A MISMATCHED base pair can CAUSE a distortion in the geometry of the double helix, which is RECOGNIZABLE by a repair enzyme. This process of repairing is called mismatch repair.

66.

Which repair system operates to repair DNA strands that are actively transcribed?(a) Double-strand breakage repair(b) Nucleotide excision repair(c) RNA repair(d) Messenger RNA repairI got this question by my college director while I was bunking the class.My query is from DNA Repair topic in chapter DNA Replication and Repair, Cellular Reproduction of Cell Biology

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Correct ANSWER is (b) Nucleotide EXCISION repair

For explanation I would say: The template strands of genes that are actively being TRANSCRIBED are REPAIRED by the transcription coupled pathway of the nucleotide excision repair (NER) system.

67.

Which enzyme joins the Okazaki fragments into a continuous strand?(a) gyrase(b) topoisomerase(c) ligase(d) helicaseThis question was addressed to me in class test.I would like to ask this question from DNA Replication in section DNA Replication and Repair, Cellular Reproduction of Cell Biology

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The correct answer is (c) LIGASE

The best explanation: The Okazaki fragments are synthesized discontinuously in 3’ to 5’ direction and then later joined into a CONTINUOUS STRAND by the enzyme DNA ligase. This strand is termed as the lagging strand.