InterviewSolution
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InterviewSolution
This section includes InterviewSolutions, each offering curated multiple-choice questions to sharpen your knowledge and support exam preparation. Choose a topic below to get started.
| 1. |
Cyclic AMP binds to (A) Catalytic subunits of protein kinase (B) Regulatory subunits of protein kinase (C) Catalytic subunits of phosphorylase kinase (D) Regulatory subunits of phosphorylase kinase |
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Answer» (B) Regulatory subunits of protein kinase |
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| 2. |
Feedback inhibition of enzyme is influenced by (A) Enzyme (B) External factors (C) End product (D) Substrate |
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Answer» (C) End product |
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| 3. |
At low blood glucose concentration, brain but not liver will take up glucose. It is due to the (A) Low Km of hexokinase (B) Low Km of glucokinase (C) Specificity of glucokinase (D) Blood brain barrier |
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Answer» (A) Low Km of hexokinase |
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| 4. |
Since pepsin is a gastric enzyme does it have an acid or basic optimum pH? What happens to pepsin when it passes into the duodenum? |
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Answer» Pepsin acts within the stomach so its optimum pH is around 2, an acid pH. When the enzyme passes into the duodenum it meets a higher pH and its enzyme activity ends. |
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| 5. |
Template/lock and key theory of enzyme action is supported by (A) Enzymes speed up reaction (B) Enzymes occur in living beings and speed up certain reactions (C) Enzymes determine the direction of reaction (D) Compounds similar to substrate inhibit enzyme activity |
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Answer» (D) Compounds similar to substrate inhibit enzyme activity |
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| 6. |
Fischer’s ‘lock and key’ model of the enzyme action implies that (A) The active site is complementary in shape to that of substance only after interaction. (B) The active site is complementary in shape to that of substance (C) Substrates change conformation prior to active site interaction (D) The active site is flexible and adjusts to substrate |
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Answer» (B) The active site is complementary in shape to that of substance |
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| 7. |
Glycolysis is anaerobic in (A) Liver (B) Brain (C) Kidneys (D) Erythrocytes |
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Answer» Glycolysis is anaerobic in Erythrocytes. |
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| 8. |
‘Lock’ and ‘Key’ theory was proposed by(A) Sorenson(B) Fischer(C) Mehler(D) Sanger |
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Answer» ‘Lock’ and ‘Key’ theory was proposed by Sanger. |
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| 9. |
Which of the following enzymes incorporates inorganic phosphate into the substrate? (A) Phosphoglycerate kinase (B) Glyceraldehyde-3-phosphate dehydrogenase (C) Pyruvate kinase (D) Enolase |
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Answer» (A) Phosphoglycerate kinase |
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| 10. |
In erythrocytes, 2, 3-biphosphoglycerate is derived from the intermediate: (A) Glyeraldehyde-3-phosphate (B) 1, 3-Biphosphoglycerate (C) 3-Phosphoglycerate (D) 2-Phosphoglycerate |
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Answer» (B) 1, 3-Biphosphoglycerate |
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| 11. |
A unique by-product of glycolysis in erythrocytes is (A) Lactate (B) 1, 3-Biphosphoglycerate (C) 2, 3-Biphosphoglycerate (D) All of these |
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Answer» (C) 2, 3-Biphosphoglycerate |
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| 12. |
Key and lock hypothesis of enzyme action was given by (A) Fischer (B) Koshland (C) Buchner (D) Kuhne |
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Answer» Key and lock hypothesis of enzyme action was given by Fischer. |
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| 13. |
The amino alcohol sphingosine is synthesized in (A) Mitochondria (B) Cytosol (C) Nucleus (D) Endoplasmic reticulum |
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Answer» (D) Endoplasmic reticulum |
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| 14. |
Dry seeds endure higher temperature than germinating seeds as (A) Hydration is essential for making enzymes sensitive to temperature (B) Dry seeds have a hard covering(C) Dry seeds have more reserve food (D) Seedlings are tender |
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Answer» (A) Hydration is essential for making enzymes sensitive to temperature |
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| 15. |
Who suggested that enzymes are proteinaceous? (A) Buchner (B) Kuhne (C) Sumner (D) Pasteur |
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Answer» Sumner suggested that enzymes are proteinaceous. |
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| 16. |
Glucose cannot be synthesized from (A) Glycerol (B) Lactate (C) Alanine (D) Leucine |
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Answer» Glucose cannot be synthesized from Leucine. |
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| 17. |
Enzymes, vitamins and hormones are common in (A) Being proteinaceous (B) Being synthesized in the body of organisms (C) Enhancing oxidative metabolism (D) Regulating metabolism |
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Answer» (D) Regulating metabolism |
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| 18. |
What is the action mechanism of the antiretroviral drugs called protease inhibitors which are used against HIV infection? |
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Answer» Protease inhibitors are some of the antiretroviral drugs used to treat HIV infection. Protease is an enzyme necessary for the assembling of HIV after the synthesis of its proteins within the host cell. The protease inhibitor binds to the activation centre of the enzyme blocking the formation of the enzyme-substrate complex and the enzyme activity thus impairing the viral replication. |
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| 19. |
Physostigmine is a competitive inhibitor of (A) Xanthine oxidase (B) Cholinesterase (C) Carbonic anhydrase (D) Monoamine oxidase |
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Answer» (B) Cholinesterase |
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| 20. |
The harmone acting directly on intestinal mucosa and stimulating glucose absorption is (A) Insulin (B) Glucagon (C) Thyroxine (D) Vasopressin |
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Answer» (C) Thyroxine |
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| 21. |
Alkaline phosphatase is present in (A) Liver (B) Bones (C) Intestinal mucosa (D) All of these |
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Answer» (D) All of these |
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| 22. |
The normal GPT activity ranges from (A) 60.0–250.0 IU/L (B) 4.0–17.0 IU/L (C) 3.0–15.0 IU/L (D) 0.1–14.0 IU/L |
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Answer» (C) 3.0–15.0 IU/L |
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| 23. |
The normal serum acid phosphatase activity ranges from (A) 5.0–13.0 KA units/100 ml (B) 1.0–5.0 KA units/100 ml (C) 13.0–18.0 KA units/100 ml (D) 0.2–0.8 KA units/100 ml |
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Answer» (B) 1.0–5.0 KA units/100 ml |
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| 24. |
The cyclisation of squalene in mammals results in the direct formation of the sterol. (A) Cholesterol (B) Lanosterol (C) Sistosterol (D) Zymosterol |
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Answer» (B) Lanosterol |
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| 25. |
Which one of the following transfers acyl groups? (A) Thiamine pyrophosphate (B) Lipomide (C) ATP (D) NADH |
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Answer» (B) Lipomide |
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| 26. |
Which one of the following enzymes requires a coenzyme derived from the vitamin whose structure is shown below? (A) Enoyl CoA hydratase (B) Phosphofructokinase (C) Glucose-6-phosphatase (D) Glucose-6-phosphate dehydrogenase |
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Answer» (D) Glucose-6-phosphate dehydrogenase |
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| 27. |
All of the following are allosteric enzymes except (A) Citrate synthetase (B) a-Ketoglutarate dehdrogenase (C) Succinate thiokinase (D) Succinate dehydrogenase |
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Answer» (C) Succinate thiokinase |
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| 28. |
The enzyme -ketoglutarate dehydrogenase in the citric acid cycle requires (A) Lipoate (B) Folate (C) Pyridoxine (D) Inositol |
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Answer» The enzyme -ketoglutarate dehydrogenase in the citric acid cycle requires Lipoate. |
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| 29. |
The reaction catalysed by α-ketoglutarate dehydrogenase in the citric acid cycle requires (A) NAD (B) NADP (C) ADP (D) ATP |
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Answer» The Correct option is (A) NAD |
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| 30. |
Malonate is an inhibitor of (A) Malate dehydrogenase (B) α-Ketoglutarate dehydrogenase (C) Succinate dehydrogenase (D) Isocitrate dehydrogenase |
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Answer» (C) Succinate dehydrogenase |
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| 31. |
All of the following intermediates of citric acid cycle can be formed from amino acids except (A) α-Ketoglutarate (B) Fumarate (C) Malate (D) Oxaloacetate |
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Answer» The Correct option is (C) Malate |
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| 32. |
All of the following are intermediates of citric acid cycle except (A) Oxalosuccinate (B) Oxaloacetate (C) Pyruvate (D) Fumarate |
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Answer» (C) Pyruvate |
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| 33. |
Which one of the following cofactors must be utilized during the conversion of acetyl CoA to malonyl CoA? (A) TPP (B) ACP (C) NAD+ (D) Biotin |
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Answer» The Correct option is (D) Biotin |
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| 34. |
In TCA cycle, oxalosuccinate is converted to α-ketoglutarate by the enzyme: (A) Fumarase (B) Isocitrate dehydrogenase (C) Aconitase (D) Succinase |
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Answer» (B) Isocitrate dehydrogenase |
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| 35. |
If all the enzymes, intermediates and cofactors of the citric acid cycle as well as an excess of the starting substrate acetyl CoA are present and functional in an organelle free solution at the appropriate pH, which of the following factors of the citric acid cycle would prove to be rate limiting? (A) Molecular oxygen (B) Half life of enzyme (C) Turnover of intermediates (D) Reduction of cofactors |
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Answer» (D) Reduction of cofactors |
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| 36. |
A carrier molecule in the citric acid cycle is (A) Acetyl-CoA (B) Citrate (C) Oxaloacetate (D) Malate |
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Answer» (C) Oxaloacetate |
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| 37. |
In reversible non-competitive enzyme activity inhibition (A) Inhibitor bears structural resemblance to substrate (B) Inhibitor lowers the maximum velocity attainable with a given amount of enzyme (C) Km is increased (D) Km is decreased |
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Answer» (B) Inhibitor lowers the maximum velocity attainable with a given amount of enzyme |
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| 38. |
Enzyme inhibition caused by a substance resembling substrate molecule is (A) Competitive inhibition(B) Non-competitive inhibition (C) Feedback inhibition (D) Allosteric inhibition |
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Answer» (A) Competitive inhibition |
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| 39. |
The enzyme using some other substance, not oxygen as hydrogen acceptor is (A) Tyrosinase (B) Succinate dehydrogenase (C) Uricase (D) Cytochrome oxidase |
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Answer» (B) Succinate dehydrogenase |
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| 40. |
An enzyme which uses hydrogen acceptor as substrate is (A) Xanthine oxidase (B) Aldehyde oxidase (C) Catalase (D) Tryptophan oxygenase |
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Answer» (C) Catalase |
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| 41. |
An enzyme catalyzing oxidoreduction, using oxygen as hydrogen acceptor is (A) Cytochrome oxidase (B) Lactate dehydrogenase (C) Malate dehydrogenase (D) Succinate dehydrogenase |
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Answer» (A) Cytochrome oxidase |
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| 42. |
Defective enzyme in Hunter’s syndrome is (A) α-L-iduronidase (B) Iduronate sulphatase (C) Arylsulphatase B (D) C-acetyl transferase |
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Answer» (B) Iduronate sulphatase |
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| 43. |
Chain elongation of fatty acids in mammalian liver occurs in (A) Nucleus (B) Ribosomes (C) Lysosomes (D) Microsomes |
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Answer» Chain elongation of fatty acids in mammalian liver occurs in Microsomes. |
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| 44. |
Brown adipose tissue is (A) A prominent tissue in human (B) Characterised by high content of mitochondria (C) Associated with high activity of ATP synthase (D) Characterised by low content of cytochromes |
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Answer» (B) Characterised by high content of mitochondria |
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| 45. |
α-Galactosidase enzyme is defective in (A) Tay-sach’s disease (B) Refsum’s disease (C) Sandhoff’s disease (D) Fabry’s disease |
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Answer» (D) Fabry’s disease |
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| 46. |
An important finding in Refsum’s disease is (A) Accumulation of ceramide trihexoside in the kidney (B) Accumulation of phytanic acid in the blood and tissues (C) Accumulation of gangliosides in brain and spleen (D) Skin eruptions |
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Answer» (B) Accumulation of phytanic acid in the blood and tissues |
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| 47. |
The major site for elongation of medium chain fatty acids is (A) Mitochondria (B) Cytosol (C) Microsomes (D) All of these |
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Answer» (C) Microsomes |
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| 48. |
The principal action of insulin in adipose tissue is to inhibit the activity of the (A) Hormone sensitive lipoprotein lipase (B) Glycerol phosphate acyltransferase (C) Acetyl-CoA carboxylase (D) Pyruvate dehydrogenase |
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Answer» (A) Hormone sensitive lipoprotein lipase |
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| 49. |
The enzyme that converts glucose to glucose-6-phosphate is (A) Phosphatase (B) Hexokinase (C) Phosphorylase (D) Glucose synthetase |
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Answer» (B) Hexokinase |
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| 50. |
An important finding in Hyperammonemia type II is (A) Increased serum gluatmine level (B) Enlarged liver (C) Mental retardation (D) Increased carbamoyl phosphate synthetase level |
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Answer» (C) Mental retardation |
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